Orchard Therapeutics and SIRION Biotech Announce Licensing Agreement to Enhance Gene Therapy Manufacturing Efficiency
“At Orchard Therapeutics, we are establishing manufacturing capabilities to deliver potentially transformative gene therapy products to rare disease patients around the globe. Optimization of lentiviral transduction through a technology such as LentiBOOST™, along with the build-out of our recently announced manufacturing facility, are representative of our continued efforts to increase efficiencies and further streamline our approach to manufacturing gene therapy candidates,” said
Under the terms of the agreement, SIRION will provide Orchard with a license to its proprietary lentiviral transduction enhancer LentiBOOST™ for development and commercialization activities for select Orchard programs. SIRION will be entitled to upfront and milestone payments and is eligible to receive royalties on net sales of future products that utilize the LentiBOOST™ technology.
“LentiBOOST™ was designed to enhance lentiviral transduction performance for difficult cell types like primary T-cells and hematopoietic stem cells,” said Dr.
Orchard’s portfolio of autologous ex vivo gene therapies includes Strimvelis, the first autologous ex vivo gene therapy approved by the
Orchard currently has offices in the
SIRION Biotech was founded in 2005 with the goal to spark a new generation of viral vector technologies for gene and cell therapy as well as vaccine development. This meant evolving novel therapeutic viral vectors and technology platforms based on lenti-, adeno-, - and adeno-associated viruses, to expedite its partners’ advances in drug development. LentiBOOST™ is applied in a couple of clinical trials from early stage clinical phase I/II up to late stage clinical phase III trials and demonstrated clinical success in improving transduction of the therapeutic vector.
This press release contains certain forward-looking statements which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements may be identified by words such as “anticipates,” “believes,” “expects,” “intends,” “projects,” “anticipates,” and “future” or similar expressions that are intended to identify forward-looking statements. Forward-looking statements include express or implied statements relating to, among other things, the ability of LentiBOOST™ technology to improve efficiencies in drug product manufacturing processes and the results of any pre-clinical and clinical trials of Orchard’s product candidates using LentiBOOST™ technology. These statements are neither promises nor guarantees, but are subject to a variety of risks and uncertainties, many of which are beyond Orchard’s control, which could cause actual results to differ materially from those contemplated in these forward-looking statements. In particular, the risks and uncertainties include, without limitation, the risk that expected outcomes from the license agreement with
LifeSci Public Relations
For SIRION Biotech
Source: Orchard Therapeutics